The Single Best Strategy To Use For ceesdekker.net
The Single Best Strategy To Use For ceesdekker.net
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Our group studies bacterial mobile division and is particularly aiming to constitute a ‘bottom up biology’ in synthetic cells that can autonomously divide. Our main desire lies in cell division, chromatin framework, and spatial Management.
[Laughs] ‘It was unquestionably a terrific hazard! At the time, I had been perfectly conscious that it could go Incorrect and that I could become much less productive, but I just disregarded that. Curiosity has normally been my strongest driving drive. And by chance all of it worked out.’
Sculpting nano-electrodes with a transmission electron beam for electrical and geometrical characterization of nanoparticles.
That could be a desire of mine and we set to work which has a delightful dose of naivety. This really is something which will most likely yield magnificent ends in the lengthier time period, but that does not issue. You shouldn't only want to operate around the issues of tomorrow, but also to the concerns in the working day just after tomorrow.’
Our analysis ranges within the biophysics of DNA to synthetic cells and outside of. Be sure to take a look down below in the spectrum of our present tasks.
A lot of linked developments adopted, where by our team founded different transistor variants such as single-electron transistors at room temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled numerous transistors into little proof-of-principle electronic circuits.
Studying DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
‘Of course, I comprehend people today were amazed at the time. At the conclusion of the nineties, when I was in my forties, I used to be Professor of Molecular Electronics and I've to admit that it had turn into a little bit bored, I didn’t find out A great deal any more. The sector went extra into the applying facet, how you may combine nanotubes into Digital circuits.
But carbon nanotubes have remained a research topic of considerable desire to lots of. In truth, the outlook on using carbon nanotubes to build practical equipment, in spots which include radio-frequency electronics, electronic electronics and flexible electronics, remains vibrant.
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
‘That fears the synthetic mobile, as part of the Dutch BaSyC initiative. Craig Venter seemed major-down in Individuals times and identified about five hundred genes which have been minimally needed for your functioning cell. We wish to look base-up: how can we move from a several molecules to a complete biological process?
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-assortment conformational variations in Mre11/DNA fix complexes; and to start with power measurements ceesdekker.net with a DNA molecule inside a nanopore
Good-point out nanopores have proven to be a remarkably adaptable probe for one-molecule Assessment of DNA. I'll explain several of our new results – specially DNA knots – together with our initiatives to grow the capabilities of sound-state nanopores even additional, within the direction of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.